Sunday, January 14, 2018

Muscle fatigue, mitochondrial exhaustion, lactic acid, and the supplements that can help

Here is some miscellaneous info and links that I've found interesting.  I'm posting them, partially so I'll review them again later, and partially for anyone who may also find this information helpful.  As always, be careful when trying diet changes, supplements, etc. with these sensitive horses.

Mitochondrial Exhaustion, DMG, Pyruvate Conversion:

B Vitamins and Metabolic Syndromes:

B Vitamin Deficiencies and Neurological Disorders:

  • Associations between B Vitamins and Parkinson's Disease  "B vitamins may correlate with Parkinson's disease (PD) through regulating homocysteine level..."
  • Nicotinic acid decreases serum thyroid hormone levels while maintaining a euthyroid state  "These results suggest that nicotinic acid decreases serum thyroid hormone concentrations while maintaining a euthyroid state. This effect may be mediated through reduction in thyroxine-binding globulin, but other mechanisms may also be involved..."
  • B vitamins and berries and age-related neurodegenerative disorders  "The current research on B vitamins is largely inadequate to confidently assess their mechanisms of action on age-related neurocognitive disorders, their associations with disease, or their effectiveness as supplements. B vitamin supplementation may be of value for neurocognitive function, but the evidence is inconclusive..."
  • Managing a Hot Horse from a Nutritional Perspective  "A sugar-like carbohydrate, inositol is one of the lesser known B vitamins and also referred to as vitamin B8. Inositol is critical for messages sent between different cells, particularly those found in the brain and spinal tissues. The use of inositol oral supplementation has been proven highly effective in treating mental disorders in humans such as anxiety, obsessive compulsive disorder, and depression without any known side effects. While not found frequently in equine calming supplements, this is certainly a nutraceutical that is gaining traction...  The primary role of tryptophan in the body is as a precursor to the neurotransmitter serotonin. Serotonin is a neurotransmitter produced by the lining of the gastrointestinal tract and helps digestive movements and clotting of the blood in the case of injury. Serotonin also helps contribute to an animal’s sense of satiation and, thereby, directly impacts behavior. If an animal is satiated by its resource availability, it has been shown that he will be more agreeable and less quarrelsome. Adequate tryptophan levels and, subsequently, serotonin levels help the animal determine that he does not have to “fight” as much for resources, resulting in a more amicable horse. When humans eating diets low in tryptophan were examined, the deficiency of tryptophan also correlated with lower serotonin levels and more aggressive and depressive behaviors."

Other Topics of Interest:

Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions - 2008

More research that I intend to add links/info to in the near future: Nrf2, Nrf2 MSM

About the Artist:

horse artist, equine artist, PSSM horse
Since starting my art business in 2004, I have been on a roller coaster ride that's taken me from art, to house flipping, to legal assistant, to horse trainer, and a full 180* back to my artworks.

I'm thankful to get back to my art, and also for the life experiences I've gained.

Things in life that matter the most!  Jen, husband Jared, and Jax

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